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Polarization-extinction-based detection of DNA hybridization in situusing a nanoparticle wire-grid polarizer |
Optics Letters, Vol. 37, Issue 18, pp. 3867-3869 (2012)
http://dx.doi.org/10.1364/OL.37.003867
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Abstract
Metallic wires can discriminate light polarization due to strong absorption of electric fields oscillating in parallel to wires. Here, we explore polarization-based biosensing of DNA hybridization in situ by employing metal target-conjugated nanoparticles to form a wire-grid polarizer (WGP) as complementary DNA strands hybridize. Experimental results using gold nanoparticles of 15 nm diameter to form a WGP of 400 nm period suggest that polarization extinction can detect DNA hybridization with a limit of detection in the range of 1 nM concentration. The sensitivity may be improved by more than an order of magnitude if larger nanoparticles are employed to define WGPs at a period between 400 and 500 nm.
© 2012 Optical Society of America
OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(230.5440) Optical devices : Polarization-selective devices
(280.1415) Remote sensing and sensors : Biological sensing and sensors
ToC Category:
Optical Devices
History
Original Manuscript: July 10, 2012
Revised Manuscript: July 31, 2012
Manuscript Accepted: July 31, 2012
Published: September 14, 2012
Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics
Citation
Hojeong Yu, Youngjin Oh, Soowon Kim, Seok Ho Song, and Donghyun Kim, "Polarization-extinction-based detection of DNA hybridization in situusing a nanoparticle wire-grid polarizer," Opt. Lett. 37, 3867-3869 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-18-3867
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