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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 11 — Oct. 31, 2012

Optical coherence tractography using intrinsic contrast

Craig J. Goergen, Harsha Radhakrishnan, Sava Sakadžić, Emiri T. Mandeville, Eng H. Lo, David E. Sosnovik, and Vivek J. Srinivasan  »View Author Affiliations

Optics Letters, Vol. 37, Issue 18, pp. 3882-3884 (2012)

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Organs such as the heart and brain possess intricate fiber structures that are best characterized with three-dimensional imaging. For instance, diffusion-based, magnetic resonance tractography (MRT) enables studies of connectivity and remodeling during development and disease macroscopically on the millimeter scale. Here we present complementary, high-resolution microscopic optical coherence imaging and analysis methods that, when used in conjunction with clearing techniques, can characterize fiber architecture in intact organs at tissue depths exceeding 1 mm. We anticipate that these techniques can be used to study fiber architecture in situ at microscopic scales not currently accessible to diffusion magentic resonance (MR), and thus, to validate and complement macroscopic structural imaging techniques. Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes.

© 2012 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 30, 2012
Revised Manuscript: July 11, 2012
Manuscript Accepted: July 20, 2012
Published: September 14, 2012

Virtual Issues
Vol. 7, Iss. 11 Virtual Journal for Biomedical Optics

Craig J. Goergen, Harsha Radhakrishnan, Sava Sakadžić, Emiri T. Mandeville, Eng H. Lo, David E. Sosnovik, and Vivek J. Srinivasan, "Optical coherence tractography using intrinsic contrast," Opt. Lett. 37, 3882-3884 (2012)

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  1. D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, E. H. Sonnenblick, Circ. Res. 24, 339 (1969). [CrossRef]
  2. T. G. Reese, R. M. Weisskoff, R. N. Smith, B. R. Rosen, R. E. Dinsmore, V. J. Wedeen, Magn. Reson. Med. 34, 786 (1995). [CrossRef]
  3. V. J. Wedeen, R. P. Wang, J. D. Schmahmann, T. Benner, W. Y. Tseng, G. Dai, D. N. Pandya, P. Hagmann, H. D’Arceuil, A. J. de Crespigny, NeuroImage 41, 1267 (2008). [CrossRef]
  4. M. F. G. Wood, N. Ghosh, M. A. Wallenburg, S.-H. Li, R. D. Weisel, B. C. Wilson, R.-K. Li, I. A. Vitkin, J. Biomed. Opt. 15, 047009 (2010). [CrossRef]
  5. C. Vinegoni, D. Razansky, J.-L. Figueiredo, M. Nahrendorf, V. Ntziachristos, R. Weissleder, Opt. Lett. 34, 319 (2009). [CrossRef]
  6. C. P. Fleming, C. M. Ripplinger, B. Webb, I. R. Efimov, A. M. Rollins, J. Biomed. Opt. 13, 030505 (2008). [CrossRef]
  7. H. Wang, A. J. Black, J. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, T. Akkin, NeuroImage 58, 984 (2011). [CrossRef]
  8. J. B. Arous, J. Binding, J.-F. Leger, M. Casado, P. Topilko, S. Gigan, A. C. Boccara, L. Bourdieu, J. Biomed. Opt. 16, 116012 (2011). [CrossRef]
  9. H. Hama, H. Kurokawa, H. Kawano, R. Ando, T. Shimogori, H. Noda, K. Fukami, A. Sakaue-Sawano, A. Miyawaki, Nat. Neurosci. 14, 1481 (2011). [CrossRef]
  10. V. J. Srinivasan, H. Radhakrishnan, J. Y. Jiang, S. Barry, A. E. Cable, Opt. Express 20, 2220 (2012). [CrossRef]

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