Antiresonance-guiding hollow-core fibers are shown to enable highly sensitive detection of cell proliferation probes using Raman scattering within the region where the cellular Raman activity is minimal. We demonstrate that such fibers can substantially reduce the level of the background compared to standard index-guiding optical fibers, thus radically improving the sensitivity of Raman detection of DNA synthesis in cells and offering a powerful tool for fiber-based live-cell imaging.
© 2012 Optical Society of America
Original Manuscript: August 7, 2012
Manuscript Accepted: September 8, 2012
Published: November 7, 2012
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics
Lyubov V. Doronina-Amitonova, Il’ya V. Fedotov, Andrei B. Fedotov, Konstantin V. Anokhin, Ming-lie Hu, Ching-yue Wang, and Aleksei M. Zheltikov, "Raman detection of cell proliferation probes with antiresonance-guiding hollow fibers," Opt. Lett. 37, 4642-4644 (2012)