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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 1 — Feb. 4, 2013

High-speed interferometric spectrally encoded flow cytometry

Lior Golan, Daniella Yeheskely-Hayon, Limor Minai, and Dvir Yelin  »View Author Affiliations


Optics Letters, Vol. 37, Issue 24, pp. 5154-5156 (2012)
http://dx.doi.org/10.1364/OL.37.005154


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Abstract

Spectrally encoded flow cytometry (SEFC) is a promising technique for noninvasive in vivo microscopy of blood cells. Here, we introduce a novel SEFC system for label-free confocal imaging of blood cells flowing at velocities of up to 10mm/s within 65 μm-diameter vessels. The new system employs interferometric Fourier-domain detection and a high-speed wavelength-swept source, allowing 100 kHz line rate, sufficient for sampling the rapidly flowing cells 80 μm below the tissue surface. The large data sets obtained by this technique would improve diagnosis accuracy, reduce imaging time, and open new possibilities for noninvasive monitoring of blood in patients.

© 2012 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1650) Medical optics and biotechnology : Coherence imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 2, 2012
Revised Manuscript: November 5, 2012
Manuscript Accepted: November 19, 2012
Published: December 11, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Lior Golan, Daniella Yeheskely-Hayon, Limor Minai, and Dvir Yelin, "High-speed interferometric spectrally encoded flow cytometry," Opt. Lett. 37, 5154-5156 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-24-5154

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