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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 6 — May. 25, 2012

Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms

Adam K. Glaser, Rongxiao Zhang, Scott C. Davis, David J. Gladstone, and Brian W. Pogue  »View Author Affiliations


Optics Letters, Vol. 37, Issue 7, pp. 1193-1195 (2012)
http://dx.doi.org/10.1364/OL.37.001193


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Abstract

Radiation from a linear accelerator induces Cherenkov emission in tissue, which has recently been shown to produce biochemical spectral signatures that can be interpreted to estimate tissue hemoglobin and oxygen saturation or molecular fluorescence from reporters. The Cherenkov optical light levels are in the range of 106 to 109W/cm2, which limits the practical utility of the signal in routine radiation therapy monitoring. However, due to the fact that the radiation is pulsed, gated-acquisition of the signal allows detection in the presence of ambient lighting, as is demonstrated here. This observation has the potential to significantly increase the value of Cherenkov emission spectroscopy during radiation therapy to monitor tissue molecular events.

© 2012 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 4, 2011
Revised Manuscript: December 13, 2011
Manuscript Accepted: December 21, 2011
Published: March 26, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Adam K. Glaser, Rongxiao Zhang, Scott C. Davis, David J. Gladstone, and Brian W. Pogue, "Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms," Opt. Lett. 37, 1193-1195 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-37-7-1193


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References

  1. P. A. Cherenkov, Phys. Rev. 52, 378 (1937). [CrossRef]
  2. R. Robertson, M. S. Germanos, C. Li, G. S. Mitchell, S. R. Cherry, and M. D. Silva, Phys. Med. Biol. 54, N355 (2009). [CrossRef]
  3. A. E. Spinelli, D. D’Ambrosio, L. Calderan, M. Marengo, A. Sbarbati, and F. Boschi, Phys. Med. Biol. 55, 483 (2010). [CrossRef]
  4. H. Liu, G. Ren, Z. Miao, X. Zhang, X. Tang, P. Han, S. S. Gambhir, and Z. Cheng, PLoS ONE 5, e9470 (2010). [CrossRef]
  5. A. Ruggiero, J. P. Holland, J. S. Lewis, and J. J. Grimm, J. Nucl. Med. 51, 1123 (2010). [CrossRef]
  6. C. Li, G. S. Mitchell, and S. R. Cherry, Opt. Lett. 35, 1109 (2010). [CrossRef]
  7. R Robertson, M. S. Germanos, M. G. Manfredi, P. G Smith, and M. D. Silva, J. Nucl. Med. 52, 1764 (2011). [CrossRef]
  8. G. S. Mitchell, R. K. Gill, D. L. Boucher, C Li, and S. R. Cherry, Philos. Trans. Roy. Soc. A 369, 4605 (2011). [CrossRef]
  9. J. Axelsson, S. C. Davis, D. J. Gladstone, and B. W. Pogue, Med. Phys. 38 (7), 4127 (2011). [CrossRef]
  10. J. Axelsson, A. K. Glaser, D. J. Gladstone, and B. W. Pogue, Opt. Express20, 5133 (2012).. [CrossRef]
  11. L. A. Brody, E. R. Strupinsky, and L. R. Kline, Active Packaging for Food Applications (CRC Press, 2001), Chap. 3.
  12. P. Vaupel, A. Mayer, and M. Höckel in Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology, M. R. Nowrousian, eds. (Springer, 2008) pp. 265–282.
  13. S. M. Evans and C. J. Koch, Cancer Lett. 195, 1 (2003). [CrossRef]
  14. M. Nordsmark, S. M. Bentzen, V. Rudat, D. Brizel, E. Lartigau, P. Stadler, A. Becker, M. Adam, M. Molls, J. Dunst, D. J. Terris, and J. Overgaard, Radiother. Oncol. 77, 18 (2005). [CrossRef]
  15. R. A. Cooper, C. M. West, J. P. Logue, S. E. Davidson, A. Miller, S. Roberts, I. J. Statford, D. J. Honess, and R. D. Hunter, Int. J. Radiat. Oncol. Biol. Phys. 45, 119 (1999). [CrossRef]

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