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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 7 — Aug. 1, 2013

Quantitative fluorescence diffuse optical tomography in the presence of heterogeneities

Teresa Correia, Nicolas Ducros, Cosimo D’Andrea, Martin Schweiger, and Simon Arridge  »View Author Affiliations

Optics Letters, Vol. 38, Issue 11, pp. 1903-1905 (2013)

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In fluorescence diffuse optical tomography (fDOT), the accuracy of reconstructed fluorescence distributions highly depends on the knowledge of the tissue optical heterogeneities for correct modeling of light propagation. Common approaches are to assume homogeneous optical properties or, when structural information is available, assign optical properties to various segmented organs, which is likely to result in inaccurate reconstructions. Furthermore, DOT based only on intensity (continuous wave-DOT) is a nonunique inverse problem, and hence, cannot be used to retrieve simultaneously maps of absorption and diffusion coefficients. We propose a method that reconstructs a single parameter from the excitation measurements, which is used in the fDOT problem to accurately recover fluorescence distribution.

© 2013 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 26, 2012
Revised Manuscript: February 22, 2013
Manuscript Accepted: May 1, 2013
Published: May 27, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Teresa Correia, Nicolas Ducros, Cosimo D’Andrea, Martin Schweiger, and Simon Arridge, "Quantitative fluorescence diffuse optical tomography in the presence of heterogeneities," Opt. Lett. 38, 1903-1905 (2013)

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