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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 8 — Sep. 4, 2013

Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography

Robert W. Holt, Scott Davis, and Brian W. Pogue  »View Author Affiliations


Optics Letters, Vol. 38, Issue 14, pp. 2407-2409 (2013)
http://dx.doi.org/10.1364/OL.38.002407


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Abstract

The use of anatomical priors in fluorescence tomography is known to improve image quality and accuracy significantly. However, the use of prior information is often implemented by incorporating user segmented structural images into the optical reconstruction algorithm, a process requiring significant time and expertise. We propose an automated implementation which encodes the gray-scale prior image directly into the regularization term, eliminating the need for direct prior image segmentation, which is extendable to any spatially defined prior data. The proposed method is supported by in vivo studies.

© 2013 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 1, 2013
Revised Manuscript: June 10, 2013
Manuscript Accepted: June 10, 2013
Published: July 5, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Robert W. Holt, Scott Davis, and Brian W. Pogue, "Regularization functional semi-automated incorporation of anatomical prior information in image-guided fluorescence tomography," Opt. Lett. 38, 2407-2409 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-14-2407


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