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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 8 — Sep. 4, 2013

Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth

Yong Zhou, Junjie Yao, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 38, Issue 14, pp. 2592-2595 (2013)
http://dx.doi.org/10.1364/OL.38.002592


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Abstract

Due to strong light scattering in tissue, both the spatial resolution and maximum penetration depth of optical-resolution photoacoustic microscopy (OR-PAM) deteriorate sharply with depth. To reduce tissue scattering, we propose to use glycerol as an optical clearing agent in OR-PAM. Our results show that the imaging performance of OR-PAM can be greatly enhanced by optical clearing both in vitro and in vivo.

© 2013 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6930) Medical optics and biotechnology : Tissue
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 3, 2013
Manuscript Accepted: June 13, 2013
Published: July 15, 2013

Virtual Issues
Vol. 8, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Yong Zhou, Junjie Yao, and Lihong V. Wang, "Optical clearing-aided photoacoustic microscopy with enhanced resolution and imaging depth," Opt. Lett. 38, 2592-2595 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-14-2592

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