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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 9 — Oct. 2, 2013

Axicon lens-based cone shell configuration for depth-sensitive fluorescence measurements in turbid media

Yi Hong Ong and Quan Liu  »View Author Affiliations


Optics Letters, Vol. 38, Issue 15, pp. 2647-2649 (2013)
http://dx.doi.org/10.1364/OL.38.002647


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Abstract

We have developed a novel noncontact setup to implement a cone shell illumination and detection configuration using axicon lenses for depth-sensitive fluorescence measurements. The setup was demonstrated experimentally to be capable of detecting fluorescence from a two-layered turbid agar phantom with a larger sensitivity to the deep layer and a larger range of sensitivity to either layer than a conventional cone configuration implemented by a microscope objective lens. Furthermore, the axicon lens-based setup eliminates the need of moving the objective lens up or down to achieve depth-sensitive measurements, which effectively improves the consistency of optical coupling and thus would be preferred in a clinical setting.

© 2013 Optical Society of America

OCIS Codes
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(110.0113) Imaging systems : Imaging through turbid media
(110.2945) Imaging systems : Illumination design

ToC Category:
Imaging Systems

History
Original Manuscript: April 11, 2013
Revised Manuscript: May 27, 2013
Manuscript Accepted: June 6, 2013
Published: July 19, 2013

Virtual Issues
Vol. 8, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Yi Hong Ong and Quan Liu, "Axicon lens-based cone shell configuration for depth-sensitive fluorescence measurements in turbid media," Opt. Lett. 38, 2647-2649 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-15-2647

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