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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 9 — Oct. 2, 2013

Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, and Natan T. Shaked  »View Author Affiliations

Optics Letters, Vol. 38, Issue 16, pp. 3017-3020 (2013)

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We achieved continuous, noncontact wide-field imaging and characterization of drug release from a polymeric device in vitro by uniquely using off-axis interferometric imaging. Unlike the current gold-standard methods in this field, which are usually based on chromatography and spectroscopy, our method requires no user intervention during the experiment and involves less lab consumable instruments. Using a simplified interferometric imaging system, we experimentally demonstrate the characterization of anesthetic drug release (Bupivacaine) from a soy-based protein matrix, which is used as a skin substitute for wound dressing. Our results demonstrate the potential of interferometric imaging as an inexpensive and easy-to-use alternative for characterization of drug release in vitro.

© 2013 Optical Society of America

OCIS Codes
(090.0090) Holography : Holography
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.4630) Instrumentation, measurement, and metrology : Optical inspection
(120.4640) Instrumentation, measurement, and metrology : Optical instruments
(160.5470) Materials : Polymers
(160.1435) Materials : Biomaterials

ToC Category:
Instrumentation, Measurement, and Metrology

Original Manuscript: June 5, 2013
Revised Manuscript: July 9, 2013
Manuscript Accepted: July 15, 2013
Published: August 7, 2013

Virtual Issues
Vol. 8, Iss. 9 Virtual Journal for Biomedical Optics

Haniel Gabai, Maya Baranes-Zeevi, Meital Zilberman, and Natan T. Shaked, "Continuous wide-field characterization of drug release from skin substitute using off-axis interferometry," Opt. Lett. 38, 3017-3020 (2013)

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