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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 10 — Nov. 8, 2013

Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging

K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg  »View Author Affiliations


Optics Letters, Vol. 38, Issue 18, pp. 3566-3569 (2013)
http://dx.doi.org/10.1364/OL.38.003566


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Abstract

We present the results of a feasibility study with spatial frequency domain imaging (SFDI) to produce quantitative measurements of optical property and chromophore concentration maps of three porcine kidneys utilizing a renal occlusion model at the near-infrared wavelengths of 658, 730, and 850 nm. Using SFDI, we examined the dynamics of absolute oxygen saturation (StO2). The mean StO2 for the kidneys varied from approximately 60% before occlusion, to 20% during occlusion, to 55% after reperfusion. We also present, for the first time to the best of our knowledge, reduced scattering coefficient (μs) maps of the kidney during occlusion. We observed a substantial decrease in the wavelength dependence of scattering (i.e., scattering power) in the three kidneys, with a mean decrease of 18%±2.6%, which is indicative of an increase in scatterer size, and is likely due to tissue changes such as edema that follow from occlusion and inflammation.

© 2013 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7230) Medical optics and biotechnology : Urology
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 11, 2013
Manuscript Accepted: July 15, 2013
Published: September 6, 2013

Virtual Issues
Vol. 8, Iss. 10 Virtual Journal for Biomedical Optics

Citation
K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg, "Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging," Opt. Lett. 38, 3566-3569 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-18-3566


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