We present a method, intensity fluctuation modulation (IFM), to obtain a full-field laser speckle microvessel image. Different from laser speckle contrast analysis, IFM imaging is insensitive to flow velocity and can be used to reconstruct microvessel images with higher spatial resolution and SNR. An in vivo animal experiment on a mouse pinna is conducted to demonstrate that IFM imaging is capable of achieving laser speckle microangiography.
© 2013 Optical Society of America
Original Manuscript: January 21, 2013
Revised Manuscript: March 17, 2013
Manuscript Accepted: March 18, 2013
Published: April 10, 2013
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics
Yaguang Zeng, Mingyi Wang, Guangping Feng, Xianjun Liang, and Guojian Yang, "Laser speckle imaging based on intensity fluctuation modulation," Opt. Lett. 38, 1313-1315 (2013)