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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 6 — Jun. 27, 2013

Deep tissue flowmetry based on diffuse speckle contrast analysis

Renzhe Bi, Jing Dong, and Kijoon Lee  »View Author Affiliations


Optics Letters, Vol. 38, Issue 9, pp. 1401-1403 (2013)
http://dx.doi.org/10.1364/OL.38.001401


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Abstract

Diffuse correlation spectroscopy (DCS) is an emerging modality for noninvasive deep tissue blood flow monitoring that is becoming increasingly popular; it conducts an autocorrelation analysis of fast fluctuating photon count signals from a single speckle. In this Letter, we show that the same level of deep tissue flow information can be obtained from a much simpler analysis on the spatial distribution of the speckles that is obtained by a CCD camera, which we named diffuse speckle contrast analysis (DSCA). Both the flow phantom experiment and in vivo cuff occlusion data are presented. DSCA can be considered a new optical modality that combines DCS and laser speckle contrast imaging (LSCI), which exploits simple instrumentation and analysis and yet is sensitive to deep tissue flow.

© 2013 Optical Society of America

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(290.1990) Scattering : Diffusion

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 28, 2012
Revised Manuscript: January 9, 2013
Manuscript Accepted: March 18, 2013
Published: April 24, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Renzhe Bi, Jing Dong, and Kijoon Lee, "Deep tissue flowmetry based on diffuse speckle contrast analysis," Opt. Lett. 38, 1401-1403 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-9-1401

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