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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 6 — Jun. 27, 2013

Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging

Shuna Cheng, J. Jesus Rico-Jimenez, Joey Jabbour, Bilal Malik, Kristen C. Maitland, John Wright, Yi-Shing Lisa Cheng, and Javier A. Jo  »View Author Affiliations


Optics Letters, Vol. 38, Issue 9, pp. 1515-1517 (2013)
http://dx.doi.org/10.1364/OL.38.001515


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Abstract

Fluorescence lifetime imaging (FLIM) offers a noninvasive approach for characterizing the biochemical composition of biological tissue. There has been an increasing interest in the application of multispectral FLIM for medical diagnosis. Central to the clinical translation of FLIM technology is the development of compact and high-speed endoscopy systems. Unfortunately, the predominant multispectral FLIM approaches suffer from limitations that impede the development of endoscopy systems that are suitable for in vivo tissue imaging. We present a compact wide-field time-gated FLIM flexible endoscope capable of continuous lifetime imaging of up to three fluorescence emission bands simultaneously. This endoscope design will facilitate the evaluation of FLIM for in vivo applications.

© 2013 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 22, 2013
Revised Manuscript: March 26, 2013
Manuscript Accepted: March 26, 2013
Published: April 26, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Shuna Cheng, J. Jesus Rico-Jimenez, Joey Jabbour, Bilal Malik, Kristen C. Maitland, John Wright, Yi-Shing Lisa Cheng, and Javier A. Jo, "Flexible endoscope for continuous in vivo multispectral fluorescence lifetime imaging," Opt. Lett. 38, 1515-1517 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-9-1515


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