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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 6 — Jun. 27, 2013

Use of hyperspectral imaging for label-free decoding and detection of biomarkers

Tongzhou Wang, Qiang Li, Xin Li, Songmin Zhao, Ying Lu, and Guoliang Huang  »View Author Affiliations


Optics Letters, Vol. 38, Issue 9, pp. 1524-1526 (2013)
http://dx.doi.org/10.1364/OL.38.001524


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Abstract

Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2ng/mm2 without fluorescent labeling.

© 2013 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(100.4145) Image processing : Motion, hyperspectral image processing

ToC Category:
Image Processing

History
Original Manuscript: January 24, 2013
Revised Manuscript: March 27, 2013
Manuscript Accepted: March 27, 2013
Published: April 29, 2013

Virtual Issues
Vol. 8, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Tongzhou Wang, Qiang Li, Xin Li, Songmin Zhao, Ying Lu, and Guoliang Huang, "Use of hyperspectral imaging for label-free decoding and detection of biomarkers," Opt. Lett. 38, 1524-1526 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-38-9-1524


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