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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 3 — Mar. 6, 2014

Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy

Rehman Ansari, Christian Myrtus, Redouane Aherrahrou, Jeanette Erdmann, Achim Schweikard, and Gereon Hüttmann  »View Author Affiliations


Optics Letters, Vol. 39, Issue 1, pp. 45-47 (2014)
http://dx.doi.org/10.1364/OL.39.000045


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Abstract

We present an ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy (SD-OCPM) system that combines submicrometer transverse spatial resolution and subnanometer optical path length sensitivity, with an acquisition speed of over 217,000voxels/s. The proposed SD-OCPM system overcomes two significant drawbacks of traditional common-path interferometers—limited transverse spatial resolution and suboptimal detection sensitivity—while maintaining phase stability that is comparable with common-path interferometer setups. The transverse and axial spatial resolution of the setup is measured to be 0.6 and 1.9 μm, respectively, with a phase sensitivity of 0.0027 rad (corresponds to optical path length sensitivity of 110 pm). High-speed acquisition allows for phase-sensitive 4D imaging of biological samples with subcellular resolution.

© 2013 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.1650) Imaging systems : Coherence imaging
(170.0180) Medical optics and biotechnology : Microscopy
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(180.6900) Microscopy : Three-dimensional microscopy

ToC Category:
Imaging Systems

History
Original Manuscript: September 23, 2013
Revised Manuscript: November 15, 2013
Manuscript Accepted: November 18, 2013
Published: December 19, 2013

Virtual Issues
Vol. 9, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Rehman Ansari, Christian Myrtus, Redouane Aherrahrou, Jeanette Erdmann, Achim Schweikard, and Gereon Hüttmann, "Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy," Opt. Lett. 39, 45-47 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-39-1-45

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Supplementary Material


» Media 1: AVI (1291 KB)     

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