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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 3 — Mar. 6, 2014

Quantitative Mueller matrix fluorescence spectroscopy for precancer detection

J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh  »View Author Affiliations


Optics Letters, Vol. 39, Issue 2, pp. 243-246 (2014)
http://dx.doi.org/10.1364/OL.39.000243


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Abstract

Quantitative fluorescence spectroscopic Mueller matrix measurements from the connective tissue regions of human cervical tissue reveal intriguing fluorescence diattenuation and polarizance effects. Interestingly, the estimated fluorescence linear diattenuation and polarizance parameters were considerably reduced in the precancerous tissues as compared to the normal ones. These polarimetry effects of the autofluorescence were found to originate from anisotropically organized collagen molecular structures present in the connective tissues. Consequently, the reduction of the magnitude of these polarimetric parameters at higher grades of precancer was attributed to the loss of anisotropic organization of collagen, which was also confirmed by control experiments. These results indicate that fluorescence spectral diattenuation and polarizance parameters may serve as potentially useful diagnostic metrics.

© 2014 Optical Society of America

OCIS Codes
(120.5410) Instrumentation, measurement, and metrology : Polarimetry
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence
(170.6935) Medical optics and biotechnology : Tissue characterization
(240.2130) Optics at surfaces : Ellipsometry and polarimetry

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 23, 2013
Revised Manuscript: November 27, 2013
Manuscript Accepted: December 2, 2013
Published: January 6, 2014

Virtual Issues
Vol. 9, Iss. 3 Virtual Journal for Biomedical Optics

Citation
J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh, "Quantitative Mueller matrix fluorescence spectroscopy for precancer detection," Opt. Lett. 39, 243-246 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-39-2-243


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