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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 5 — Apr. 29, 2014

Tomographic lifetime imaging using combined early- and late-arriving photons

Steven S. Hou, William L. Rice, Brian J. Bacskai, and Anand T. N. Kumar  »View Author Affiliations


Optics Letters, Vol. 39, Issue 5, pp. 1165-1168 (2014)
http://dx.doi.org/10.1364/OL.39.001165


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Abstract

We present a novel, hybrid approach for time domain fluorescence tomography that efficiently combines lifetime multiplexing using late-arriving or asymptotic photons, with the high spatial resolution capability of early photon tomography. We also show that a decay amplitude-based asymptotic approach is superior to direct inversion of late-arriving photons for tomographic lifetime imaging within turbid media. The hybrid reconstruction approach is experimentally shown to recover fluorescent inclusions separated as close as 1.4 mm, with improved resolution and reduced cross talk compared to just using early photons or the asymptotic approach alone.

© 2014 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3650) Medical optics and biotechnology : Lifetime-based sensing
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 5, 2013
Manuscript Accepted: January 16, 2014
Published: February 20, 2014

Virtual Issues
Vol. 9, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Steven S. Hou, William L. Rice, Brian J. Bacskai, and Anand T. N. Kumar, "Tomographic lifetime imaging using combined early- and late-arriving photons," Opt. Lett. 39, 1165-1168 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ol-39-5-1165


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