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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 38, Iss. 3 — Feb. 1, 2013
  • pp: 266–268

Dual-modality needle probe for combined fluorescence imaging and three-dimensional optical coherence tomography

Dirk Lorenser, Bryden C. Quirk, Mathieu Auger, Wendy-Julie Madore, Rodney W. Kirk, Nicolas Godbout, David D. Sampson, Caroline Boudoux, and Robert A. McLaughlin  »View Author Affiliations


Optics Letters, Vol. 38, Issue 3, pp. 266-268 (2013)
http://dx.doi.org/10.1364/OL.38.000266


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Abstract

To the best of our knowledge, we present the first needle probe for combined optical coherence tomography (OCT), and fluorescence imaging. The probe uses double-clad fiber (DCF) that guides the OCT signal and fluorescence excitation light in the core and collects and guides the returning fluorescence in the large-diameter multimode inner cladding. It is interfaced to a 1310 nm swept-source OCT system that has been modified to enable simultaneous 488 nm fluorescence excitation and >500nm emission detection by using a DCF coupler to extract the returning fluorescence signal in the inner cladding with high efficiency. We present imaging results from an excised sheep lung with fluorescein solution infused through the vasculature. We were able to identify alveoli, bronchioles, and blood vessels. The results demonstrate that the combined OCT plus fluorescence needle images provide improved tissue differentiation over OCT alone.

© 2013 Optical Society of America

OCIS Codes
(060.2370) Fiber optics and optical communications : Fiber optics sensors
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 24, 2012
Revised Manuscript: December 7, 2012
Manuscript Accepted: December 16, 2012
Published: January 16, 2013

Virtual Issues
Vol. 8, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Dirk Lorenser, Bryden C. Quirk, Mathieu Auger, Wendy-Julie Madore, Rodney W. Kirk, Nicolas Godbout, David D. Sampson, Caroline Boudoux, and Robert A. McLaughlin, "Dual-modality needle probe for combined fluorescence imaging and three-dimensional optical coherence tomography," Opt. Lett. 38, 266-268 (2013)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-38-3-266


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