OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 11 — Jun. 1, 2014
  • pp: 3328–3331

Confocal photoacoustic microscopy using a single multifunctional lens

Lei Xi, Chaolong Song, and Huabei Jiang  »View Author Affiliations

Optics Letters, Vol. 39, Issue 11, pp. 3328-3331 (2014)

View Full Text Article

Enhanced HTML    Acrobat PDF (437 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Photoacoustic microscopy (PAM) has remained one of the fastest developing biomedical imaging modalities in the past decade. The confocal strategy of optical illumination and acoustic detection is a way to boost the sensitivity of PAM. To achieve confocal PAM, current PAM systems utilize separate acoustic and optical converging devices, making the systems bulky and complicated. In this Letter, we demonstrate the use of a single-liquid lens to successfully achieve acoustic and optical confocal configuration for optical-resolution PAM (ORPAM). Using the lens with a numerical aperture of 0.43, we show that the resolution of the ORPAM system is 4.8 μm with a significantly improved sensitivity of acoustic detection. We also apply this compact ORPAM system to in vivo imaging of the vasculature of a rat ear.

© 2014 Optical Society of America

OCIS Codes
(080.3630) Geometric optics : Lenses
(110.0180) Imaging systems : Microscopy
(110.5120) Imaging systems : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 28, 2014
Revised Manuscript: April 7, 2014
Manuscript Accepted: April 26, 2014
Published: May 30, 2014

Virtual Issues
Vol. 9, Iss. 8 Virtual Journal for Biomedical Optics

Lei Xi, Chaolong Song, and Huabei Jiang, "Confocal photoacoustic microscopy using a single multifunctional lens," Opt. Lett. 39, 3328-3331 (2014)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. P. Beard, Interface Focus 1, 602 (2011). [CrossRef]
  2. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, Nat. Biotechnol. 24, 848 (2006). [CrossRef]
  3. L. Xi, L. Zhou, and H. Jiang, Appl. Phys. Lett. 101, 013702 (2012). [CrossRef]
  4. L. V. Wang and S. Hu, Science 335, 1458 (2012). [CrossRef]
  5. X. Yang, X. Cai, K. Maslov, L. V. Wang, and Q. Luo, Chin. Opt. Lett. 8, 609 (2010). [CrossRef]
  6. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, Opt. Lett. 33, 929 (2008). [CrossRef]
  7. Y. Yuan, S. Yang, and D. Xing, Appl. Phys. Lett. 100, 023702 (2012). [CrossRef]
  8. C. Song, L. Xi, and H. Jiang, Opt. Lett. 38, 2930 (2013). [CrossRef]
  9. C. Song, L. Xi, and H. Jiang, J. Appl. Phys. 114, 194703 (2013). [CrossRef]
  10. G. C. Knollman, J. L. S. Bellin, and J. L. Weaver, J. Acoust. Soc. Am. 49, 253 (1971). [CrossRef]
  11. N. Sugiura and S. Morita, Appl. Opt. 32, 4181 (1993). [CrossRef]
  12. C. Song, N. T. Nguyen, S. H. Tan, and A. K. Asundi, Lab Chip 9, 1178 (2009). [CrossRef]
  13. C. Song, N. T. Nguyen, S. H. Tan, and A. K. Asundi, Microfluid. Nanofluid. 9, 889 (2010). [CrossRef]
  14. K. H. Song and L. V. Wang, J. Biomed. Opt. 12, 060503 (2007). [CrossRef]
  15. J. T. Walsh, T. J. Flotte, and T. F. Deutsch, Lasers Surg. Med. 9, 314 (1989). [CrossRef]
  16. V. P. Zharov, E. I. Galanzha, E. V. Shashkov, N. G. Khlebtsov, and V. V. Tuchin, Opt. Lett. 31, 3623 (2006). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited