OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 12 — Jun. 15, 2014
  • pp: 3414–3417

Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles

Xiaohua Feng, Fei Gao, and Yuanjin Zheng  »View Author Affiliations

Optics Letters, Vol. 39, Issue 12, pp. 3414-3417 (2014)

View Full Text Article

Enhanced HTML    Acrobat PDF (487 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Thermally modulated photoacoustic imaging (TMPI) is reported here for contrast enhancement when using nanoparticles as contrast agents. Exploiting the excellent sensitivity of the photoacoustic (PA) process on temperature and the highly selective heating capability of nanoparticles under electromagnetic field, the PA signals stemming from the nanoparticles labeled region can be efficiently modulated whereas those from highly light absorptive backgrounds are minimally affected. A coherent difference imaging procedure reduces the background signal and thus improves the imaging contrast. Phantom experiments with super-paramagnetic iron oxide nanoparticles (SPIONs) as contrast agents and alternating magnetic fields for heating are demonstrated. Further improvements toward clinical applications are also discussed.

© 2014 Optical Society of America

OCIS Codes
(060.4080) Fiber optics and optical communications : Modulation
(110.5120) Imaging systems : Photoacoustic imaging
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Imaging Systems

Original Manuscript: February 17, 2014
Revised Manuscript: April 15, 2014
Manuscript Accepted: May 3, 2014
Published: June 4, 2014

Xiaohua Feng, Fei Gao, and Yuanjin Zheng, "Thermally modulated photoacoustic imaging with super-paramagnetic iron oxide nanoparticles," Opt. Lett. 39, 3414-3417 (2014)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. L. H. V. Wang and S. Hu, Science 335, 1458 (2012). [CrossRef]
  2. Z. Yuan and H. B. Jiang, Appl. Phys. Lett. 88, 231101 (2006). [CrossRef]
  3. D. Razansky, C. Vinegoni, and V. Ntziachristos, Opt. Lett. 32, 2891 (2007). [CrossRef]
  4. G. Ku and L. H. V. Wang, Opt. Lett. 30, 507 (2005). [CrossRef]
  5. E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. L. Yang, and V. P. Zharov, Nat. Nanotechnol. 4, 855 (2009). [CrossRef]
  6. A. De La Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T. J. Ma, O. Oralkan, Z. Cheng, X. Y. Chen, H. J. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, Nat. Nanotechnol. 3, 557 (2008). [CrossRef]
  7. Y. D. Jin, C. X. Jia, S. W. Huang, M. O’Donnell, and X. H. Gao, Nat. Commun. 1, 1 (2010). [CrossRef]
  8. M. Qu, S. Mallidi, M. Mehrmohammadi, R. Truby, K. Homan, P. Joshi, Y. S. Chen, K. Sokolov, and S. Emelianov, Biomed. Opt. Express 2, 385 (2011). [CrossRef]
  9. V. P. Zharov, Nat. Photonics 5, 110 (2011). [CrossRef]
  10. C. W. Wei, M. Lombardo, K. Larson-Smith, I. Pelivanov, C. Perez, J. Xia, T. Matula, D. Pozzo, and M. O’Donnell, Appl. Phys. Lett. 104, 033701 (2014). [CrossRef]
  11. A. Athanasiou, M. Tardivon, B. Tanter, J. Sigal-Zafrani, T. D. Bercoff, J. L. Eux, M. Gennisson, Fink, and S. Neuenschwander, Radiology 256, 297 (2010). [CrossRef]
  12. L. Gao, L. D. Wang, C. Y. Li, Y. Liu, H. X. Ke, C. Zhang, and L. H. V. Wang, J. Biomed. Opt. 18, 026003 (2013). [CrossRef]
  13. M. Pramanik and L. V. Wang, J. Biomed. Opt. 14, 054024 (2009). [CrossRef]
  14. M. Babincova, V. Altanerova, C. Altaner, P. Cicmanec, and P. Babinec, Med. Phys. 31, 2219 (2004). [CrossRef]
  15. A. Mashal, B. Sitharaman, X. Li, P. K. Avti, A. V. Sahakian, J. H. Booske, and S. C. Hagness, IEEE Trans. Biomed. Eng. 57, 1831 (2010). [CrossRef]
  16. C. J. Gannon, P. Cherukuri, B. I. Yakobson, L. Cognet, J. S. Kanzius, C. Kittrell, R. B. Weisman, M. Pasquali, H. K. Schmidt, R. E. Smalley, and S. A. Curley, Cancer 110, 2654 (2007). [CrossRef]
  17. S. H. Wang, C. W. Wei, S. H. Jee, and P. C. Li, Proc. SPIE 7177, 71771S (2009).
  18. L. D. Wang, J. Xia, J. J. Yao, K. I. Maslov, and L. H. V. Wang, Phys. Rev. Lett. 111, 204301 (2013). [CrossRef]
  19. L. M. Nie, Z. M. Ou, S. H. Yang, and D. Xing, Med. Phys. 37, 4193 (2010). [CrossRef]
  20. R. E. Rosensweig, J. Magn. Magn. Mater. 252, 370 (2002). [CrossRef]
  21. Cervadoro, C. Giverso, R. Pande, S. Sarangi, L. Preziosi, J. Wosik, A. Brazdeikis, and P. Decuzzi, PLoS ONE 8, e57332 (2013). [CrossRef]
  22. J. H. Lee, J. T. Jang, J. S. Choi, S. H. Moon, S. H. Noh, J. W. Kim, J. G. Kim, I. S. Kim, K. I. Park, and J. Cheon, Nat. Nanotechnol. 6, 418 (2011). [CrossRef]
  23. H. Huang, S. Delikanli, H. Zeng, D. M. Ferkey, and A. Pralle, Nat. Nanotechnol. 5, 602 (2010). [CrossRef]
  24. M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, J. Biomed. Opt. 14, 034018 (2009). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited