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Optics Letters

Optics Letters


  • Editor: Xi-Cheng Zhang
  • Vol. 39, Iss. 16 — Aug. 15, 2014
  • pp: 4731–4734

Handheld photoacoustic microscopy to detect melanoma depth in vivo

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 39, Issue 16, pp. 4731-4734 (2014)

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We developed handheld photoacoustic microscopy (PAM) to detect melanoma and determine tumor depth in nude mice in vivo. Compared to our previous PAM system for melanoma imaging, a new light delivery mechanism is introduced to improve light penetration. We show that melanomas with 4.1 and 3.7 mm thicknesses can be successfully detected in phantom and in in vivo experiments, respectively. With its deep melanoma imaging ability and handheld design, this system can be tested for clinical melanoma diagnosis, prognosis, and surgical planning for patients at the bedside.

© 2014 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 23, 2014
Manuscript Accepted: June 13, 2014
Published: August 6, 2014

Virtual Issues
Vol. 9, Iss. 10 Virtual Journal for Biomedical Optics

Yong Zhou, Wenxin Xing, Konstantin I. Maslov, Lynn A. Cornelius, and Lihong V. Wang, "Handheld photoacoustic microscopy to detect melanoma depth in vivo," Opt. Lett. 39, 4731-4734 (2014)

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