An inverse algorithm is presented for tomographically imaging morphologic characteristics of nonspherical particles in heterogeneous turbid media. The particles are assumed to have spheroidal shapes with random orientations. The inverse algorithm is based on a relationship of the particle scattering spectra, obtained from multispectral diffuse optical tomography, and the size, concentration, and aspect ratio of spheroidal particles through the T-matrix method. The algorithm is implemented based on Tikhonov–Marquardt regularization techniques that minimize the difference between the observed and calculated scattering spectra. Different statistical models are assumed for the suspended nonspherical particles and the performance of the inverse algorithm is tested using noise-corrupted data up to 50% noise added to the observed scattering spectra.
© 2011 Optical Society of America
Original Manuscript: March 9, 2011
Revised Manuscript: May 6, 2011
Manuscript Accepted: May 10, 2011
Published: July 13, 2011
Vol. 6, Iss. 8 Virtual Journal for Biomedical Optics
M. Reza Hajihashemi and Huabei Jiang, "T-matrix-based inverse algorithm for morphologic characterization of nonspherical particles using multispectral diffuse optical tomography," Appl. Opt. 50, 3896-3906 (2011)