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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 3 — Feb. 29, 2012

Rapid high resolution imaging of diffusive properties in turbid media

Frank Scheffold and Ian D. Block  »View Author Affiliations


Optics Express, Vol. 20, Issue 1, pp. 192-200 (2012)
http://dx.doi.org/10.1364/OE.20.000192


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Abstract

We propose a laser speckle based scheme that allows the analysis of local scattering properties of light diffusely reflected from turbid media. This turbid medium can be a soft material such as a colloidal or polymeric material but can also be biological tissue. The method provides a 2D map of the scattering properties of a complex, multiple scattering medium by recording a single image. We demonstrate that the measured speckle contrast can be directly related to the local transport mean free path l* or the reduced scattering coefficient μt = 1/l* of the medium. In comparison to some other approaches, the method does not require scanning (of a laser beam, detector or the sample itself) in order to generate a spatial map. It can conveniently be applied in a reflection geometry and provides a single characteristic value at any given position with an intrinsic resolution typically on the order of 5–50 μm. The actual resolution is however limited by the transport mean free path itself and can thus range from microns to millimeters.

© 2011 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(110.6150) Imaging systems : Speckle imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Imaging Systems

History
Original Manuscript: September 20, 2011
Revised Manuscript: November 24, 2011
Manuscript Accepted: November 28, 2011
Published: December 20, 2011

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Frank Scheffold and Ian D. Block, "Rapid high resolution imaging of diffusive properties in turbid media," Opt. Express 20, 192-200 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=oe-20-1-192


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